While Peripheral Nervous System conditions account for the majority of Ig use in neurology, there is a small, but growing, use of Ig for Central Nervous System (CNS) conditions. In order to address this need a working group made up of neurologists, CNS specialists and transfusion medicine physicians was established to develop treatment recommendation for IVIg use for CNS conditions in BC. These recommendations, along with additional resources, are intended to support clinicians in diagnosing and managing these conditions. The program will officially launch on February 1, 2023 with the intention to provide access to neurology expertise and to ensure appropriate Ig utilization.
Sincere thanks to the CNS Ig Use Working Group members for their time and contribution in developing these valuable resources: Dr. Robert Carruthers, Dr. Helen Cross, Dr. Jennifer Percy, Dr. Dewi Schrader, Dr. Anthony Traboulsee, and Dr. Chris Uy.
Neurologist Resources:
| Conditionally Approved |
Dated |
| Neuromyelitis Optica Spectrum Disorders (NMOSD) |
Dec 2022 |
| MOG Antibody Disease (MOGAD) | Dec 2022 |
| Acute Disseminated encephalomyelitis (ADEM) | Refer to NMOSD or MOGAD |
| Transverse Myelitis | Refer to NMOSD or MOGAD |
| Optic Neuritis | Refer to NMOSD or MOGAD |
| Stiff Person Spectrum Disorder | Dec 2022 |
| Progressive Encephalitis with Rigidity and Myoclonus (PERM) | Refer to Stiff Person Spectrum Disorder |
| Antibody Mediated Autoimmune Encephalitis (AMAE) | Dec 2022 |
| Antibody Negative Autoimmune Encephalitis (ANAE) | Refer to Antibody Mediated Autoimmune Encephalitis (AMAE) |
| CNS Complications of Systemic Vasculitis | Under development |
| Automimmune Epilepsy | Dec 2022 |
| Febrile Infection-Related Epilepsy Syndrome (FIRES) / New-Onset Refractory Status Epilepticus (NORSE) | Dec 2022 |
| Super Refractory Status Epilepticus |
Dec 2022 |
| Severe Disabling Drug Resistant Non-Surgical Epilepsy | Dec 2022 |
| Rasmussen Encephalitis | Dec 2022 |
| Childhood Epileptic Encephalopathy | Dec 2022 |
| Landau Kleffner Syndrome | Refer to Childhood Epileptic Encephalopathy |
| Electrical Status Epilepticus in Sleep Syndrome (ESES) | Refer to Childhood Epileptic Encephalopathy |
| PANDAS | Under development |
| Opsoclonus Myoclonus | Under development |
| Susac Syndrome | Dec 2022 |
| Only in Exceptional Circumstances |
Dated |
| Paraneoplastic Cerebellar Degeneration | Dec 2022 |
| Lennox Gastaut | Dec 2022 |
| Atypical Rolandic Epilepsy | Refer to Lennox Gastaut |
| West Syndrome | Refer to Lennox Gastaut |
| Multiple Sclerosis | Dec 2022 |
| Not Indicated |
Dated |
| Lupus Cerebritis | Dec 2022 |
| Myalgic Encephalitis or Chronic Fatigue Syndrome | Dec 2022 |
